Latest article: |
Natural Products Targeting Oncology Pathways
04 May 2010: In this application note, BioFocus present three examples for natural compounds targeting specific tumor pathways: geldanamycin, borrelidin and fredericamycin. Gram quantities of the compounds are generated using microbial producers and semi-synthesis subsequently generates focused libraries of natural compound analogs. In vivo and in vitro protocols are then used to test potential anticancer properties of the compounds.
BioFocus
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Recent articles: |
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Epigenetics Targets –Efficient Hit-Finding Approaches
04 May 2010: In this application note BioFocus use epigenetic targets to identify starting points for lead optimizaton. In order to address a broad range of novel epigenetics targets, rather than screening a full compound collection, BioFocus use computational chemistry workflows which are individually tailored and optimized for selecting the most suited compounds from library subsets for primary screening. These filtered high-throughput screens generate a greatly increased hit-rate.
BioFocus
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Are Natural Products Delivering? Experiences and Recommendations from 27 Screening Campaigns
04 May 2010: In this application note from BioFocus, microbial strain subfractions are generated and used in high-throughput screens (HTS) for analysis with regard to diversity, selectivity and strain origin. Natural compounds were identified during the follow up of subfraction screening programs and their chemical properties have been analyzed. Searches in natural product databases revealed that 135 of the 645 identified natural compounds are novel compounds.
BioFocus
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New Frontiers: The Changing World of Biospecimen Collection
11 Sep 2009: Revolutions in genomics and proteomics, are demanding more centralised software systems to track biological markers. This article presents the idea of a new class of ‘enterprise biobanking’ software systems, such as the Sapphire™ BioBanking Solution from LabVantage Solutions which maintain centralized records linking multiple labs around the world, integrating with LIMS and CTMS systems as well as managing the complexities surrounding the human consent forms attached to each sample.
LabVantage Solutions Inc.
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Cross sample variability analysis of an MS/MS derived MRM analysis of High Density Lipoproteins (HDL)
10 Jun 2009: This application poster demonstrates how the “Mr. M” software package was used to perform MRM analysis on human high density lipoprotein (HDL) samples. This work demonstrates maturity of the proteomics MRM approach and the ability of new software packages to perform exceedingly sensitive and accurate proteomics biomarker monitoring.
Single Organism Software Inc
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Strategies for Automated Chromatographic Method Development
 30 Jul 2008: Automated chromatographic method development has recently become a topic of considerable interest to the analytical chemistry world. The design of effective chromatographic methods is a complex task involving often conflicting goals. This paper will present new strategies for chromatographic method development that leverage modern method development tools, resulting in increases in method development efficiency.
Advanced Chemistry Development, Inc., (ACD/Labs)
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Prediction of Negative Ion Mass Fragmentation of Chloramphenicol
24 Jul 2008: There is a large amount of chemical space where deprotonation is the preferred route of ionization. ACD/MS Fragmenter software now provides fragment prediction for negative ionization modes, including deprotonation, electron capture, and hydride attachment techniques. This can make it easier for mass spectrometrists to understand and interpret these spectra. In this application note, the negative ion fragment prediction for chlorapmphenicol is examined.
Advanced Chemistry Development, Inc., (ACD/Labs)
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Prediction of Mass Fragmentation of Dextromethorphan Under Positive Electrospray Ionization Conditions
24 Jul 2008: Most ionized molecules can be broken into pieces that contain significant portions of the original structure, and these fragmentation patterns are useful in identifying unknown compounds. ACD/MS Fragmenter predicts fragment ions from chemical structures based on well established fragmentation rules. In this application note, MS Fragmenter is used to predict the fragmentation of dextromethorphan, for positive-mode electrospray ionization (ESI).
Advanced Chemistry Development, Inc., (ACD/Labs)
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Automated Logical Dilution for Ion Chromatography
 17 Jun 2008: To get accurate results in chromatography, the determined sample peak areas must be within the limits of the calibration. Moreover, high ionic concentrations can overload the column. Automated inline dilution of samples with Metrohm’s complete system of hard- and software for IC meets both challenges, thus providing accurate determinations of anions and cations.
Metrohm AG
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A Systematic Approach Towards UPLC Methods Development
 11 Jun 2008: By utilizing UltraPerformance LC (UPLC) Technology for methods development, a 6-fold improvement in throughput can be realized. In this application note, combinations of selectivity factors (pH, column chemistry and organic modifier) in UPLC separations were examined to develop high resolution chromatographic methods for separating paroxetine hydrochloride and its related compounds.
Waters
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